Caspofungin.png
Caspofungin (INN) (brand name Cancidas worldwide) is a lipopeptide antifungal drug from Merck & Co., Inc. discovered by James Balkovec, Regina Black and Frances A. Bouffard. It is a member of a new class of antifungals termed the echinocandins. It works by inhibiting the enzyme (1→3)-β-D-glucan synthase and thereby disturbing the integrity of the fungal cell wall. Caspofungin was the first inhibitor of fungal (1→3)-β-D-glucan synthesis to be approved by the United States Food and Drug Administration. Caspofungin is administered intravenously.
Specification
Item
Specifications
   Result
Appearance
White or almost white powder
Off white powder
Indentification
HPLC:The retention time of principle peak obtained from
Test solution should conform with that obtained from
Standard solution, as test in Assay
Conforms
IR: Spectrum of Test sample should conform to that
of Caspofungin Acetate Reference Standard
Conforms
Specific Optical Rotation
-102.0°~108.0 °
-105.3°
PH
5.0~7.0
6.5
Water
10.0%
7.5%
Solution color and clarity
Solution should be clear colorless
Conforms
Related substances I
Impurity A:  NMT 0.10%
ND
Impurity B:  NMT 0.10%
ND
Impurity D:  NMT 0.30%
0.17%
Impurity E:  NMT 0.10%
ND
Unspecified impurity F:  NMT 0.10%
0.03%
Unspecified impurity G:  NMT 0.10%
ND
Pneumocandin B0: NMT 0.10%
ND
Each of unspecified impurity : NMT 0.10%
0.04%
Total impurity:  NMT 1.0%
0.24%
Related substances II
Impurity C: NMT 0.10%
0.03%
Acetic acid
9.0%~11.0%(calculated on anhydrous basis)
10.1%
Heavy Metal as Pb
NMT 10ppm
Conforms

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

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