Sorafenib tosylate.jpg
Product Description:
Description: Sorafenib tosylate is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer.
Synonym: BAY 439006; BAY439006; BAY-439006; BAY 439006 Tosylate Salt; BAY 549085; Nexavar; SFN.
IUPAC/Chemical Name: 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
SMILES Code: O=C(C1=NC=CC(OC2=CC=C(C=C2)NC(NC3=CC=C(C(C(F)(F)F)=C3)Cl)=O)=C1)NC
[English Name] Sorafenib tosylate
[Test Method]HPLC
[Purity]≥99%
[CAS No.] 284461-73-0
[Mol. Formula]C21H16ClF3N4O3
[Purity]> 99% by HPLC
[Packaging]1KG,10KG;25KG/DRUM…
Package and quantity according to customer’s detail requirement
[Remark] In stock, customized for large scale.
Specifications:
Product Name
Sorafenib tosylate
Batch No.
14121501
Mfg. date
2014-12-15
Test Date
2014-12-25
Exp. date
2016-12-14
Tests
Specifications
Results
Description
White to yellowish powder, very hygroscopic.
Off-white powder, very hygroscopic.
Solubility
Freetly soluble In water and methanol and dichloromethane
Complies
Identification
       (1)By IR, To match with working standard
Complies
              (2)It gives reaction of sodium
Complies
Impurities A
≤0.1%
Not   detected
Related compounds
Any impurity   ≤0.1%
<0.1%
Total impurities ≤0.4%
0.25%
Residual Solvents
Acetidin≤ 0.5%
Not detected
Dichloromethane≤ 0.06%
Not detected
Methanol≤ 0.3%
Not detected
Acetone ≤ 0.5%
Not detected
Acetonitrile≤0.041%
Not detected
Ethanol≤0.5%
0.04%
N, N-dimethylformamide≤0.088%
Not detected
Water
≤ 5.0%
1.38%
Assay
99.0%-101.0%(On anhydrous basis)
99.98%
Conclusion
Conform to EP8.0
Packaging & Shipping:
Package:
1kg,2kg,5kg/Aluminum Bag or small package as customer’s requirement;
10kg,15kg,25kg/Drum,with food grade plastic bag inside.
Storage:
Store in a cool dry area.Keep Away from strong direct light.
Shipping:
By international express, air shipping, sea shipping.

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

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