Donepezil, marketed under the trade name Aricept, is a medication used in the palliative treatment of Alzheimer’s disease. Donepezil is used to improve cognition and behavior of people with Alzheimer’s, but does not slow the progression of or cure the disease.
Common side effects include loss of appetite, gastrointestinal upset, diarrhea, difficulty sleeping, vomiting, or muscle cramping.
It was developed by Eisai and Pfizer and is sold as a generic by multiple suppliers. Donepezil acts as a centrally acting reversible acetylcholinesterase inhibitor.
Medical uses
Alzheimer’s disease
There is no evidence that donepezil or other similar agents alters the course or progression of Alzheimer’s disease (AD). 6 to 12-month controlled studies have shown modest benefits in cognition and/or behavior. The UK National Institute for Clinical Excellence (NICE) recommends donepezil as an option in the management of mild to moderate Alzheimer’s disease. The person should, however, be reviewed frequently and if there is no significant benefit it should be stopped. In 2006 the U.S. Food and Drug Administration also approved donepezil for treatment of mild, moderate and severe dementia in Alzheimer’s disease.
Description
Superlist Name:Donepezil
Molecular Formula:C24H29NO3
CAS No.:120014-06-4
Synonyms:2-[(1-Benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Molecular Weight:379.49
Appearance:white powder
Melting Point: 207 °C
Application:Shown to increase levels of cortical acetylcholine
Specifications:
TEST ITEM
 SPECIFICATION
RESULT
Appearance
Off white to white crystalline powder
Complies
Solubility
freely  Freely soluble in chloroform, soluble
 in water and Acetic acid, slightly soluble in
 Acetonitrile  and ethanol, insoluble in
 Ethylacetoacetate and  n-hexane
Complies
Identification
(1)By IR absorption ,To match with working
 standard
Complies
(2) The retention time of the major peak of
 the sample should  accord with that of the
 working standard.
Complies
(3) Test for chlorides. Reponds to the test
 for Chlorides.
Complies
PH
4.0-7.0
6.10
Residue on ignition
≤0.1%
0.03%
Related substance
Any Unkonwn single impurity≤0.3%
Total ≤0.5%
0.04%
0.18%
Heavy metal
≤10ppm
<10ppm
Residual Solvents
Methanol≤0.3%
Ethanol≤0.5%
Ethyl acetate≤0.5%
Toluene≤0.089%
Acetic acid≤0.5%
Not detected
Not detected
Not detected
Not detected
Not detected
Loss on drying
≤0.5%
0.20%
Assay
On dried base, C24H29NO3·HCl
 should be 98.0% to 102.0%
100.20%
Conclusion: The product complies to Enterprise standard
Packing&Storage of
Package: 25kgs/drum,double plastic-bag inside, aluminum foil bag or fiber drum outside.
Storage: Stored in a clean, cool, dry area; keep away from moisture and strong, direct light/heat.
Shelf Life:Two years when properly stored.
Donepezil

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Notice: This product is only suitable for laboratory use, or the use of animals. It can not be used directly on the human body

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